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Amphetamine is known to inhibit monoamine oxidase, whereas the ability of amphetamine and its metabolites to inhibit many P450 isozymes as well as other enzymes has not been sufficiently elucidated. In vitro experiments with human microsomes show insignificant inhibition of CYP2D6 by amphetamine and insignificant inhibition of CYP1A2, 2D6, and 3A4